To calculate the statistical power for a given Type I error α, we first use equation (4) to find the critical value λ 1−α and then use equation (5) to calculate ...

Significance testing, with appropriate multiple testing correction, is currently the most convenient method for summarizing the evidence for association between a disease and a genetic variant.

Power analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required sample size for ...